I think the biggest difference is the backlot tram tour in Hollywood. That's an original. Other things they have that Florida doesn't: the Walking Dead walkthrough, the Waterworld Show, and they're getting a new version of the Jurassic Park ride.
I think if you enjoy the atmosphere of Universal, it might be worth it, but if you're there for the rides, most of it will seem like a repeat of Florida. My teens and I went to Universal Florida 2 years ago, and even though we visit CA frequently I haven't taken them to the Hollywood park.
Consider the Warner Bros. studio tour, Griffith Observatory, the zoo, etc. in the Burbank area. All of those could be half-day activities in some combination.
PHXscuba